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Computer-aided search for 5-arylideneimidazolone anticancer agents able to overcome ABCB1-based multidrug resistance
ChemMedChem. 2021 Apr 30. doi: 10.1002/cmdc.202100252. Online ahead of print.ABSTRACTABCB1 modulation is an interesting strategy in search for new anticancer agents overcoming multidrug resistance (MDR). Hence, 17 new 5-arylideneimidazolones containing amine moiety, as potential ABCB1 inhibitors was designed, synthesized, and investigated. The series was tested in both, parental (PAR) and multidrug resistant (MDR) overproducing ABCB1, T-lymphoma cancer cells using cytotoxicity assay. The ABCB1 modulating activity was examined in the rhodamine 123 accumulation test, followed by Pgp-Glo™ Assay to determine an influence of ...
Source: ChemMedChem - April 30, 2021 Category: Chemistry Authors: Aneta Kaczor Nikoletta Szemer édi Katarzyna Kucwaj-Brysz Monika D ąbrowska Ma łgorzata Starek Gniewomir Latacz Gabriella Spengler Jadwiga Handzlik Source Type: research

CD177 Expression on Neutrophils: In Search of a Clonal Assay for Myeloid Neoplasia by Flow Cytometry.
Conclusions: Skewed low neutrophil CD177(%) is highly associated with clonal myeloid disorders, particularly myelodysplasia, and may be useful for detecting clonal myeloid disorders. PMID: 24124144 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - October 15, 2013 Category: Pathology Authors: Meyerson HJ, Osei E, Schweitzer K, Blidaru G, Edinger A, Balog A Tags: Am J Clin Pathol Source Type: research

The Search for Surrogate Endpoints in Trials in Diffuse Large B-Cell Lymphoma: The Surrogate Endpoints for Aggressive Lymphoma Project.
PMID: 28798271 [PubMed - as supplied by publisher]
Source: The Oncologist - August 10, 2017 Category: Cancer & Oncology Authors: Sargent DJ, Shi Q, Flowers CR, Schmitz N, Habermann TM, Flament J, Fu T, Coiffier B, SEAL group Tags: Oncologist Source Type: research

Molecules, Vol. 25, Pages 2258: Search for ABCB1 Modulators Among 2-Amine-5-arylideneimidazolones As a New Perspective to Overcome Cancer Multidrug Resistance
a Handzlik Multidrug resistance (MDR) is a severe problem in the treatment of cancer with overexpression of glycoprotein P (Pgp, ABCB1) as a reason for chemotherapy failure. A series of 14 novel 5-arylideneimidazolone derivatives containing the morpholine moiety, with respect to two different topologies (groups A and B), were designed and obtained in a three- or four-step synthesis, involving the Dimroth rearrangement. The new compounds were tested for their inhibition of the ABCB1 efflux pump in both sensitive (parental (PAR)) and ABCB1-overexpressing (MDR) T-lymphoma cancer cells in a rhodamine 123 accumulation assay...
Source: Molecules - May 10, 2020 Category: Chemistry Authors: Aneta Kaczor M árta Nové Annam ária Kincses Gabriella Spengler Ewa Szyma ńska Gniewomir Latacz Jadwiga Handzlik Tags: Article Source Type: research

Pulmonary arterial hypertension in a patient with multiple myeloma during carfilzomib treatment: in search of better management.
CONCLUSION: The mechanism responsible for cardiac and vascular events during carfilzomib therapy is unclear. This case report highlights that it is important to define at baseline the appropriate screening of patients undergoing carfilzomib therapy with specific monitoring and symptom management and that future large prospective controlled studies are needed to define the correct monitoring strategy in refractory and relapsed multiple myeloma and the potential mechanism of vascular events. PMID: 33525991 [PubMed - as supplied by publisher]
Source: Tumori - February 4, 2021 Category: Cancer & Oncology Tags: Tumori Source Type: research

IJERPH, Vol. 18, Pages 4008: Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study
In conclusion, this questionnaire appears as a useful tool to identify NHL patients for a specialized consultation, in order to ask for compensation for occupational disease.
Source: International Journal of Environmental Research and Public Health - April 11, 2021 Category: Environmental Health Authors: Mireille Matrat Murielle Gain Corinne Haioun Fabien Le Bras Catherine Nisse Franck Morschhauser B énédicte Clin Isabelle Baldi Catherine Verdun-Esquer Robert Garnier Herv é Laborde-Castérot Fabrice H érin Yolande Esquirol Pascal Andujar Milia Belacel Tags: Article Source Type: research

Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study
In conclusion, this questionnaire appears as a useful tool to identify NHL patients for a specialized consultation, in order to ask for compensation for occupational disease.PMID:33920383 | DOI:10.3390/ijerph18084008
Source: Clinical Lymphoma and Myeloma - April 30, 2021 Category: Cancer & Oncology Authors: Mireille Matrat Murielle Gain Corinne Haioun Fabien Le Bras Catherine Nisse Franck Morschhauser B énédicte Clin Isabelle Baldi Catherine Verdun-Esquer Robert Garnier Herv é Laborde-Castérot Fabrice H érin Yolande Esquirol Pascal Andujar Milia Belacel Source Type: research

Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma
Eur J Med Chem. 2022 Sep 19;243:114761. doi: 10.1016/j.ejmech.2022.114761. Online ahead of print.ABSTRACTLymphomas are still difficult to treat even with modern therapies as, among others, multidrug resistance (MDR) is often counteracting a successful cancer therapy. P-gp/ABC-transporters are well-known for their crucial role in the main tumour MDR mechanism, eliminating drugs and cytotoxic substances from the cancer cell by efflux, and their modulators are promising for innovative therapy, but none has been approved in the pharmaceutical market yet. Herein, we have designed, synthesised and analysed 30 novel seleno- and t...
Source: European Journal of Medicinal Chemistry - September 30, 2022 Category: Chemistry Authors: Wesam Ali Sabrina Garbo Annam ária Kincses M árta Nové Gabriella Spengler Elisabetta Di Bello Ewelina Honkisz-Orzechowska Tadeusz Karcz Ewa Szyma ńska Ewa Żesławska Ma łgorzata Starek Monika D ąbrowska Wojciech Nitek Katarzyna Kucwaj-Brysz Patryk Source Type: research

Chimeric antigen receptor (CAR) T-cell therapy for people with relapsed or refractory diffuse large B-cell lymphoma
CONCLUSIONS: The available evidence on the benefits and harms of CAR T-cell therapy for people with r/r DLBCL is limited, mainly because of the absence of comparative clinical trials. The results we present should be regarded in light of this limitation and conclusions should be drawn very carefully. Due to the uncertainty in the current evidence, a large number of ongoing investigations and a risk of substantial and potentially life-threatening complications requiring supplementary treatment, it is critical to continue evaluating the evidence on this new therapy.PMID:34515338 | DOI:10.1002/14651858.CD013365.pub2
Source: Cochrane Database of Systematic Reviews - September 13, 2021 Category: General Medicine Authors: Moritz Ernst Annika Oeser Burcu Besiroglu Julia Caro-Valenzuela Mohamed Abd El Aziz Ina Monsef Peter Borchmann Lise J Estcourt Nicole Skoetz Marius Goldkuhle Source Type: research

Association Between Cancer Incidence and Mortality in Web-Based Data in China: Infodemiology Study
Conclusions: Search behaviors indeed reflect public awareness of cancer from a different angle. Research on internet search behaviors could present an innovative and timely way to monitor and estimate cancer incidence and mortality rates, especially for cancers not included in national registries.
Source: Journal of Medical Internet Research - January 29, 2019 Category: General Medicine Authors: Chenjie Xu Yi Wang Hongxi Yang Jie Hou Li Sun Xinyu Zhang Xinxi Cao Yabing Hou Lan Wang Qiliang Cai Yaogang Wang Source Type: research

A Systematic Review on Predisposition to Lymphoid (B and T cell) Neoplasias in Patients With Primary Immunodeficiencies and Immune Dysregulatory Disorders (Inborn Errors of Immunity)
Conclusions Though this is not a comprehensive summary of malignancies in PIDDs, or even lymphoproliferative disease in this area, this review summarizes the Medline-indexed published reports of B and T lymphomas in patients with PIDDs. This report highlights the diversity of malignant lymphoproliferative disorders in setting of PIDDs, and its associated challenges of diagnosis and treatment. The pathological classification and nomenclature for the lymphoid malignancies with variably reported and postulated underlying mechanisms were inconsistent and inadequate for many of these published reports. A wide range of treatmen...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

A Meta-Analysis of the Efficacy of Pomalidomide-Based Regimens for the Treatment of Relapsed/Refractory Multiple Myeloma After Lenalidomide Exposure
CONCLUSION: Pomalidomide-based combination regimens were effective in patients with RRMM previously treated with lenalidomide and tended to be associated with better outcomes when used earlier in the treatment pathway. A drug class switch may not always be necessary when making treatment decisions for patients with RRMM for whom the benefits of lenalidomide have been exhausted, although this must be supported by comparative studies.PMID:37684184 | DOI:10.1016/j.clml.2023.07.010
Source: Clinical Lymphoma and Myeloma - September 8, 2023 Category: Cancer & Oncology Authors: Faith E Davies Xavier Leleu Prisca Vogel Sujith Dhanasiri Pauline Le Nouveau Katja Weisel Source Type: research